Flow Cytometric Analysis of Lymphocyte Subsets of Covid-19 Patients from A Single Centre in Turkey
نویسندگان
چکیده
Background:
 Lymphocyte counts have been shown to negatively correlate with the severity and different outcomes in Covid-19. The aim of this single centre study is analyse distribution lymphocyte subsets response SARS-CoV-2 infection its relation severity, course prognosis disease.
 Methods:
 Blood samples were obtained from 67 consecutive patients between April 2020 July 2020. Data on other laboratory parameters, clinical collected retrospectively patient files patints defined as severe or non-severe (mild/moderate) disease. Leukocyte be studied identified by using flow cytometric analysis. Patients allocated into 3 groups based day blood sample collection for analysis: Days 0-7, 8-14 >14 Group I, II III, respectively. In 10 available an additional analysis was done 7-10 days after initial sampling.
 Results:
 Lower total lymphocyte, CD3 positive, CD4 positive B-cell compared group which also correlated high serum CRP, D-dimer ferritin levels. NK monocyte not two groups. Activation markers CD38 HLA-DR CD8 lymphocytes either group. 
 Conclusion:
 lymphopenia lower accordance previous studies associated expectancy activation met. Future detailed subgroup analyses at time-points, immune profiling vaccination well during new vaccinated will shed more light our general knowledge COVID-19 viruses general.
منابع مشابه
Healthcare Resource Management and Pandemic Preparedness for COVID-19: A Single Centre Experience From Jodhpur, India
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ژورنال
عنوان ژورنال: Ac?badem üniversitesi sa?l?k bilimleri dergisi
سال: 2023
ISSN: ['1309-470X', '1309-5994']
DOI: https://doi.org/10.31067/acusaglik.1335196